Lyon beat Wolfsburg after extra time to set up a UWCL semi-final clash with holders Arsenal Women.
Barcelona 6-0 Real Madrid (Agg: 12-2)
OL Lyonnes 4-0 (aet) Wolfsburg (Agg: 4-1)
Wolfsburg went into the tie with a slim 1-0 advantage, but that was wiped out in 16 minutes by Lily Yohannes.
With no further addition to the score in normal time despite Lyon’s pressure, extra time was needed, during which the French side struck three times.
Melchie Dumornay scored after 102 minutes, with Damaris Egurrola and Tabitha Chawinga also on target as the eight-time winners reached another final.
Arsenal will host the first leg of the semis on 25 or 26 April, with the return the following week.
Barcelona again hit Real Madrid for six, watched by over 60,000 at Camp Nou, to cruise through a semi-final against Bayern Munich.
Caroline Graham Hansen scored twice, Irene Paredes marked her 500th appearance for Barca with a goal, and Ewa Pajor and Esme Brugts also found the net.