Jess Naz could be set to make her comeback from an ACL injury for Spurs Women in the North London derby.
England international Naz, who has played over 100 times for Spurs, was sidelined following an injury last December.
Tottenham go into the clash with Arsenal four places and as many points better off than their local rivals. They have scored over three times as many goals as the Gunners but conceded twice as many.
Brighton face West Ham in the later match on Saturday with a single point between them. Lia Walti could return for the hosts, while Ebony Salmon will be back in the squad for the visitors, following on from Ffion Morgan’s comeback from injury in midweek.
Crystal Palace have home advantage over second-placed Chelsea – who might give a debut to Manaka Matsukubo – before leaders and defending champions Manchester City go to Manchester United in the late kick-off on Sunday.
Liverpool take on third-in-the-table London City, with Vivien Endemann fit to start for the Reds, while Lucy Parry and Mari Ward made their comebacks in midweek. Lionesses’ Isa Kardinaal is out for some time after suffering an ankle ligament injury in Wednesday’s match.
Everton meet Aston Villa, who claimed their first win last time out, Birmingham host a basement battle with Charlton, with City’s points coming from three draws and the Addicks without any.
Barclays WSL2 leaders Newcastle United take their 100% record to fourth-placed Nottingham Forest, who have won two games and drawn their other three so far.
A clash of third versus second sees Ipswich Town host Sunderland, who have dropped just two points to date.
Bristol City face Wolves, who are very narrowly ahead of them in fifth spot by virtue of goals scored.
Leicester City take on seventh-placed Southampton, with the Saints just goal difference ahead of the Foxes.
Burnley still search for their first-ever BWSL2 win when hosting Sheffield United, while Watford, with three draws in five, play a Durham side yet to get off the mark.
Weekend Fixtures:
Saturday 25 October
Tottenham Hotspur v Arsenal (Tottenham Hotspur Stadium, 12:45pm) – Live on BBC
Brighton & Hove Albion v West Ham United (AMEX Stadium, 5.15pm) – Live on Sky Sports
Sunday 25 October
Crystal Palace v Chelsea (Sutton Utd FC, 12pm) – Live on Sky Sports
Birmingham City v Charlton Athletic (St Andrews Stadium, 2pm) – Live on Sky Sports/YouTube
Everton v Aston Villa (Goodison Park, 2pm) – Live on Sky Sports/YouTube
Liverpool v London City Lionesses (St Helens Stadium, 2pm) – Live on Sky Sports/YouTube
Manchester United v Manchester City (Leigh Sports Village, 6pm) – Live on Sky Sports
Barclays WSL2 – All Live on BWSL2 YouTube
Watford v Durham (Vicarage Road, 12pm)
Bristol City v Wolverhampton Wanderers (Ashton Gate Stadium, 2pm)
Burnley v Sheffield United (Turf Moor, 2pm)
Ipswich Town v Sunderland (Colchester Utd FC, 2pm)
Nottingham Forest v Newcastle United (The City Ground, 2pm)
Leicester City v Southampton (King Power Stadium, 3pm)
More from the world of women’s football
Discover the latest issue of Her Goal Magazine, analysing Alexia Putellas' headline move to London City Lionesses and including a voucher to claim your FREE Women's Football Pyramid Poster 2026/27. Also featuring LCL's Isobel Goodwin, England’s Keira Barry in California, West Ham’s Nadine Riesen, Watford’s Anna Filbey and loads more from across the women's game.
Packed with exclusive interviews, player features, posters, quizzes and in-depth stories from across women’s football..
Also available from WHSmith, Morrisons, Asda, Waitrose, TG Jones and independent newsagents.