FA WNL Northern Premier Division leaders Burnley Women play West Brom at Turf Moor, while AFC Wimbledon have sold over 1,000 tickets for the clash with Southern Premier title-chasers Plymouth Argyle at Plough Lane.
The Clarets host the mid-table Baggies, holding a four-point lead over title rivals Wolves, who have two games in hand and are at home to Hull City.
While AFC Wimbledon are two points from safety in the Southern Premier, Plymouth Argyle are only behind leaders Watford from a single game more, and four ahead of AFC Bournemouth, who have three matches to catch up. The Hornets host Cheltenham, and the Cherries entertain Gwalia United.
The scrap for the Division One North top spot features a West Yorkshire derby between Leeds United and Huddersfield Town, who sit second and third respectively.
Third-placed Leafield Athletic play away at Peterborough United in Division One Midlands and really need to beat the leaders to have a realistic chance of catching them.
Fulham would expect to hold pole position in Division One South East when at basement side Chesham. Second-placed Norwich City have a late kick-off away to MK Dons at a changed venue.
Moneyfields go to fifth-placed Maidenhead, hoping to stay top of Division One South West, but Swindon Town head to Bournemouth Sports aiming to benefit from any slip-up.
FA WNL fixtures for Sunday 22 February (2pm KO):
Northern Premier Division
Burnley v West Bromwich Albion (Turf Moor)
Derby County v Sporting Khalsa (Mickleover Sports Club)
Loughborough Lightning v Liverpool Feds (Hollywell Sports Complex)
Middlesbrough v Stoke City (Stockton Town FC)
Wolverhampton Wanderers v Hull City (AFC Telford Utd)
Rugby Borough v Halifax (Rugby Borough FC)
Southern Premier Division
AFC Wimbledon v Plymouth Argyle (Plough Lane)
Lewes v Exeter City (Lewes FC)
Real Bedford v Billericay Town (Real Bedford FC)
Watford v Cheltenham Town (Uxbridge FC)
AFC Bournemouth v Gwalia United (Ringwood Town FC, 3pm)
Division One North
Chester le Street Town v Blackburn Rovers (Chester le Street Town FC)
Chorley v Doncaster Rovers Belles (Euxton Villa FC)
Leeds United v Huddersfield Town (Garforth Town AFC)
Norton & Stockton Ancients v Cheadle Town Stingers (Norton Sports Complex)
Stockport County v Durham Cestria (Stockport Sports Village)
Wythenshawe v York City (Hollyhedge Park Stadium)
Division One Midlands
Barnsley Women v Stourbridge (Steel City Stadium)
Boldmere St Michaels v Sheffield FC (The Amber Arena)
Lincoln United v Kidderminster Harriers (Lincoln Utd FC)
Northampton Town v Sutton Coldfield Town (Moulton FC)
Worcester City v Notts County (Sixways Stadium)
Leafield Athletic v Peterborough United (Castle Vale Stadium, 3pm)
Division One South East
AFC Sudbury v Luton Town (AFC Sudbury)
Chesham United v Fulham (Chesham Utd FC)
London Bees v Dulwich Hamlet (The Hive 3G)
Queens Park Rangers v Cambridge United (Hanwell Town FC)
Milton Keynes Dons v Norwich City (Bedford Town FC, 4.30pm)
Division One South West
Bournemouth Sports v Swindon Town (Chapel Gate)
Bridgwater United v Ascot United (North Somerset Community Stadium)
Bristol Rovers v Portishead Town (The Memorial Stadium)
Keynsham Town v Abingdon United (Keynsham Town FC)
Maidenhead United v Moneyfields (Maidenhead Utd FC)
Worthing v Marine Academy Plymouth (Worthing FC)
