Subway Players Cup Group Stage ties this midweek offer Aston Villa Women a chance to move to the top of the table.
Aston Villa will go top of the 23-team table should they win away at Liverpool, who currently sit just inside the top eight that will eventually qualify for the quarter-finals.
Spurs are sixth, a point ahead of visitors Crystal Palace, whom they thrashed 7-0 in the BWSL a few weeks ago.
Everton will move level on points with the current top two, presuming they defeat basement side Durham.
Brighton are seventh and host Watford, while Birmingham City face Sunderland, with both teams a point or two outside the top eight.
Top-flight strugglers Charlton Athletic host BWSL title-chasers Ipswich Town.
Fixtures for Wednesday 11 November:
Birmingham City v Sunderland (St Andrews Stadium, 7pm)
Everton v Durham (Goodison Park, 7pm)
Liverpool v Aston Villa (St Helens Stadium, 7pm)
Tottenham Hotspur v Crystal Palace (Leyton Orient FC, 7pm) – Live on BWSL YouTube
Charlton Athletic v Ipswich Town (The Valley, 7.30pm)
Brighton & Hove Albion v Watford (Crawley Town FC, 7.45pm)
The three BWSL teams in the Champions League do not compete in the Players Cup and continue their European adventures this midweek, as Chelsea travel to BK Häcken for a 5.45pm kick-off on Tuesday, and Manchester City visit Inter Milan for an 8pm start, while on Thursday Arsenal are away to Barcelona at 5.45pm.
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