Two huge clashes in the Barclays WSL see Manchester United host Chelsea on Friday and Manchester City take on Arsenal on Saturday.
Second plays first with Manchester United two points behind Chelsea who have won all four of their games. United expect to have Anna Sandberg back after illness, while Simi Awujo could make the squad for the first time this term.
Manchester City in third host an Arsenal side sitting a single point short of them, fourth-placed Spurs play Brighton, Leicester City meet Everton with both on three points and the Toffees having brought back Issy Hobson from her loan spell at Nottingham Forest and signed Man City goalkeeper Katie Startup on an emergency loan.
Liverpool head to London City looking to get off the mark, West Ham are also still chasing their first points and home to Aston Villa.
WSL 2 leaders Birmingham City entertain Southampton, Charlton are just goal-difference off the top but away to third-placed Sunderland at the Stadium of Light.
Basement side Sheffield United under interim manager Luke Turner take on Ipswich, Portsmouth sit between the Blades and Tractor Girls as they travel to Nottingham Forest.
Bristol City are home to Durham who are without a win since the opening day, Crystal Palace receive a visit from Newcastle who have lost their last two games while the Eagles are unbeaten in three.
Friday 3 October
Manchester United v Chelsea (Leigh Sports Village, 7.30pm) – Live on BBC Three/iPlayer/BBC Sport Website
Saturday 4 October
Manchester City v Arsenal (Joie Stadium, 12pm) – Live on Sky Sports
Sunday 5 October
Leicester City v Everton (King Power Stadium, 11.55am) – Live on Sky Sports/WSL YouTube
London City Lionesses v Liverpool (Bromley FC, 11.55am) – Live on Sky Sports/WSL YouTube
Tottenham Hotspur v Brighton & Hove Albion (Leyton Orient FC, 11.55am) – Live on Sky Sports
West Ham United v Aston Villa (Dagenham & Redbridge FC, 11.55am) – Live on Sky Sports
Barclays WSL 2
Sheffield United v Ipswich Town (Bramall Lane, 1pm) – Live on WSL YouTube
Birmingham City v Southampton (St Andrews, 2pm) – Live on WSL YouTube
Bristol City v Durham (Ashton Gate, 2pm) – Live on WSL YouTube
Crystal Palace v Newcastle United (Sutton Utd FC, 2pm) – Live on WSL YouTube
Nottingham Forest v Portsmouth (City Ground, 2pm) – Live on Sky Sports
Sunderland v Charlton Athletic (Stadium of Light, 2pm) – Live on WSL YouTube
